Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fenoverine
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DC Chemicals Limited
China
Product Name: Fenoverine
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Purity: 98.0%
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37561-27-6

37561-27-6 structure

37561-27-6 structure

Name: Fenoverine
Chemical Name: 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone
CAS Number: 37561-27-6
Molecular Formula: C₂₆H₂₅N₃O₃S
Molecular Weight: 459.56
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-09-24 18:42:26
Modify Date: 2024-01-02 17:17:59
Fenoverine is an antispasmodic drug and inhibits calcium channel currents[1]. Fenoverine induces rhabdomyolysis[2].

Name	2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone
Synonyms	Fenoverine Spasmopriv EINECS 253-552-1

Description	Fenoverine is an antispasmodic drug and inhibits calcium channel currents[1]. Fenoverine induces rhabdomyolysis[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
References	[1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70. [2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep;14(3):143-6.

Density	1.343g/cm3
Boiling Point	671.8ºC at 760mmHg
Molecular Formula	C₂₆H₂₅N₃O₃S
Molecular Weight	459.56
Flash Point	360.1ºC
Exact Mass	459.16200
PSA	70.55000
LogP	4.30320
Index of Refraction	1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN5445000

CHEMICAL NAME :: 10H-Phenothiazine, 10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)ace tyl)-

CAS REGISTRY NUMBER :: 37561-27-6

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H25-N3-O3-S

MOLECULAR WEIGHT :: 459.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2874 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 15,37,1989