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84379-13-5

84379-13-5 structure
84379-13-5 structure
  • Name: Bretazenil
  • Chemical Name: Bretazenil
  • CAS Number: 84379-13-5
  • Molecular Formula: C19H20BrN3O3
  • Molecular Weight: 418.284
  • Catalog: API Special medicine Antidote
  • Create Date: 2018-07-30 20:24:17
  • Modify Date: 2024-01-06 19:06:59
  • Bretazenil, also known as Ro 16-6028, is GABA A receptor agonist potentially for the treatment of anxiety disorders. Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.
Name Bretazenil
Synonyms tert-Butyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
2-Methyl-2-propanyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (13aS)-
Ro 16-6028
Ro-16-6028
tert-Butyl (S)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
Bretazenil
Density 1.6±0.1 g/cm3
Boiling Point 594.3±50.0 °C at 760 mmHg
Molecular Formula C19H20BrN3O3
Molecular Weight 418.284
Flash Point 313.2±30.1 °C
Exact Mass 417.068787
PSA 64.43000
LogP 2.52
Appearance solid | white
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.685
Storage condition 2-8°C
Water Solubility DMSO: 24 mg/mL, soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5899850
CHEMICAL NAME :
9H-Imidazo(1,5-a)pyrrolo(2,1-c)(1,4)benzodiazepine-1- carboxylic acid, 11,12,13,13a- tetrahydro-8-bromo-9-oxo-, 1,1-dimethylethyl ester, (S)-
CAS REGISTRY NUMBER :
84379-13-5
LAST UPDATED :
199806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H20-Br-N3-O3
MOLECULAR WEIGHT :
418.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>312 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,730,1988
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NJ5899850
Precursor  1

DownStream  0


Chemsrc provides CAS#:84379-13-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 84379-13-5 | Chemsrc address: https://www.chemsrc.com/en/baike/754216.html

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