152575-66-1

152575-66-1 structure

Name: BMY 45778
Chemical Name: bmy 45778
CAS Number: 152575-66-1
Molecular Formula: C₂₆H₁₈N₂O₅
Molecular Weight: 438.43
Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
Create Date: 2016-07-09 22:01:11
Modify Date: 2025-09-12 10:42:15
BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor[1].

Name	bmy 45778
Synonyms	Tocris-1442 2-[3-[4-(4,5-diphenyl-1,3-oxazol-2-yl)-1,3-oxazol-5-yl]phenoxy]acetic acid

Description	BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
References	[1]. Seiler SM, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins. 1997 Jan;53(1):21-35.