145231-45-4
145231-45-4 structure
- Name: Clobenpropit
- Chemical Name: clobenpropit
- CAS Number: 145231-45-4
- Molecular Formula: C14H19Br2ClN4S
- Molecular Weight: 470.65300
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2018-12-17 18:25:02
- Modify Date: 2025-08-25 17:08:44
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Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock[1][2].
| Name | clobenpropit |
|---|---|
| Synonyms | Clobenpropit dihydrobromide,N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothioureadihydrobromide |
| Description | Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock[1][2]. |
|---|---|
| Related Catalog | |
| Target |
H3 receptor |
| In Vivo | Clobenpropit (15 mg/kg；腹腔注射；每天一次，持续 7 天) 可抵消 MK-801 (HY-15084B) 对多巴胺和组胺水平的调节作用，并防止 MK-801 诱导的过度运动行为[1]。< br/>Clobenpropit (1、2、5 μmoL/kg；静脉注射) 对遭受失血性休克的大鼠产生复苏作用[2]。 Animal Model: 150-200g, 12-week-old male wistar albino rats[1] Dosage: 15 mg/kg Administration: I.p.; once daily for 7 days Result: Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus. Animal Model: 205-470g, adult male Wistar rats[2] Dosage: 1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days) Administration: I.v. Result: Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg). |
| References |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 551.3ºC at 760mmHg |
| Molecular Formula | C14H19Br2ClN4S |
| Molecular Weight | 470.65300 |
| Flash Point | 287.2ºC |
| Exact Mass | 467.93900 |
| PSA | 89.86000 |
| LogP | 5.86030 |
| Vapour Pressure | 3.35E-12mmHg at 25°C |
| Index of Refraction | 1.645 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |