Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Lodoxamide tromethamine
Price: ￥5846.0/1g ￥1466.0/100mg ￥736.0/25mg ￥2336.0/250mg
Purity: 95.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Lodoxamide tromethamine
Price: $400.0/100mg $650.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Lodoxamidetromethamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

63610-09-3

63610-09-3 structure

63610-09-3 structure

Name: Lodoxamide tromethamine
Chemical Name: Lodoxamidetromethamine
CAS Number: 63610-09-3
Molecular Formula: C₁₉H₂₈ClN₅O₁₂
Molecular Weight: 553.90500
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-07-14 12:04:26
Modify Date: 2024-01-05 09:59:42
Lodoxamide tromethamine (U 42585 E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

Name	Lodoxamidetromethamine
Synonyms	LodoxaMide troMethaMineon Lodoxamide (tromethamine)

Description	Lodoxamide tromethamine (U 42585 E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
In Vitro	lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1].
In Vivo	Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[2]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[3].
References	[1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94. [2]. Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7. [3]. Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.

Boiling Point	827.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₈ClN₅O₁₂
Molecular Weight	553.90500
Flash Point	454.3ºC
Exact Mass	553.14200
PSA	330.01000
Storage condition	-20℃

Hazard Codes	N