81045-50-3

81045-50-3 structure

81045-50-3 structure

Name: Pivopril
Chemical Name: (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine
CAS Number: 81045-50-3
Molecular Formula: C₁₆H₂₇NO₄S
Molecular Weight: 329.45500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2016-09-06 13:49:13
Modify Date: 2024-01-13 18:45:45
Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

Name	(S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine
Synonyms	Pivalopril Pivopril

Description	Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease
Target	ACE[1]
In Vivo	Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].
References	[1]. Burnier M, et al. RHC 3659: a new orally active angiotensin converting enzyme inhibitor in normal volunteers. Br J Clin Pharmacol. 1981 Dec;12(6):893-9. [2]. Wolf PS, et al. Angiotensin-converting enzyme inhibitory and antihypertensive activities of pivalopril (RHC 3659-(S)). Fed Proc. 1984 Apr;43(5):1322-5.

Density	1.16g/cm3
Boiling Point	490.431°C at 760 mmHg
Molecular Formula	C₁₆H₂₇NO₄S
Molecular Weight	329.45500
Flash Point	250.4±26.8 °C
Exact Mass	329.16600
PSA	99.98000
LogP	2.78420
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.531
Storage condition	2-8℃