198474-05-4
198474-05-4 structure
- Name: PF-06840003
- Chemical Name: 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
- CAS Number: 198474-05-4
- Molecular Formula: C12H9FN2O2
- Molecular Weight: 232.21000
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
- Create Date: 2017-05-21 09:25:32
- Modify Date: 2025-08-26 18:19:11
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PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor.
| Name | 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione |
|---|---|
| Synonyms |
PF-06840003
PF06840003 |
| Description | PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor. |
|---|---|
| Related Catalog | |
| Target |
IDO-1 |
| In Vitro | PF-06840003 reverses IDO-1-induced T-cell anergy in vitro[1]. |
| In Vivo | PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours[1]. |
| References |
| Molecular Formula | C12H9FN2O2 |
|---|---|
| Molecular Weight | 232.21000 |
| Exact Mass | 232.06500 |
| PSA | 65.45000 |
| LogP | 1.71300 |
| Storage condition | -20℃ |
|
~38%
198474-05-4 |
| Literature: Henon, Helene; Messaoudi, Samir; Hugon, Bernadette; Anizon, Fabrice; Pfeiffer, Bruno; Prudhomme, Michelle Tetrahedron, 2005 , vol. 61, # 23 p. 5599 - 5614 |
