2514-30-9

2514-30-9 structure

Name: PBIT
Chemical Name: 2-(4-methylphenyl)-1,2-benzothiazol-3-one
CAS Number: 2514-30-9
Molecular Formula: C₁₄H₁₁NOS
Molecular Weight: 241.31
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2017-08-30 21:41:02
Modify Date: 2024-01-05 12:04:44
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC5 s of 6 and 4.9 μM, respectively[1].

Name	2-(4-methylphenyl)-1,2-benzothiazol-3-one
Synonyms	2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one 2-(p-tolyl)benzo[d]isothiazol-3(2H)-one 2-p-Tolyl-benz[d]isothiazol-3-on 2-(4-Methylphenyl)-1,2-benzothiazol-3(2H)-one 2-p-tolyl-benz[d]isothiazol-3-one 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one 2-p-Tolyl-1,2-benzisothiazolin-3-one 2-(p-methylphenyl)-1,2-benzisothiazolin-3-one 2-(4-methylphenyl)benzo[d]isothiazol-3(2H)-one 2-p-tolyl-benzo[d]isothiazol-3-one HMS1493C06 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)- HMS2576N21 PBIT

Description	PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC5 s of 6 and 4.9 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
References	[1]. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.

RIDADR	NONH for all modes of transport