915360-05-3

915360-05-3 structure

Name: Indimitecan
Chemical Name: indimitecan
CAS Number: 915360-05-3
Molecular Formula: C₂₅H₂₁N₃O₆
Molecular Weight: 459.45100
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2017-06-06 13:26:05
Modify Date: 2024-01-08 20:10:24
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].

Name	indimitecan
Synonyms	UNII-V5T7S4HP8A 5H-(1,3)Dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione,6-(3-(1H-imidazol-1-xyl)propyl)-2,3-dimethoxy

Description	Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Top1
In Vitro	Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM[1]. Indimitecan shows potent DNA cleavage due to Top1 inhibition[1]. Indimitecan can be substrates for metabolic ketone reductases[1]. Cell Proliferation Assay[1] Cell Line: HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7 Concentration: 0-100 μM Incubation Time: Result: Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.
References	[1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012 Dec 27;55(24):10844-62.