Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ranitidine bismuth citrate
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM-- Ranitidinebismuthcitrate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

128345-62-0

128345-62-0 structure

Name: Ranitidine bismuth citrate
Chemical Name: bismuth,(E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine,2-hydroxypropane-1,2,3-tricarboxylate
CAS Number: 128345-62-0
Molecular Formula: C₁₉H₂₇BiN₄O₁₀S
Molecular Weight: 712.484
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-08-30 18:58:20
Modify Date: 2024-01-10 06:28:13
Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L[1][2][3].

Name	bismuth,(E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine,2-hydroxypropane-1,2,3-tricarboxylate
Synonyms	Azamplus 1,1-ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, bismuth(3+) salt, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1:1) (salt) 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate, bismuth(3+) salt (1:1:1) (salt) Helirad Tritec Bismuth(3+) 2-hydroxy-1,2,3-propanetricarboxylate - (Z)-N-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine (1:1:1) Pylorisan 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, (E)-, 2-hydroxy-1,2,3-propanetricarboxylate, bismuth(3+) salt (1:1:1) (salt) Pylorid bismuth(3+) 2-hydroxypropane-1,2,3-tricarboxylate - (Z)-N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine (1:1:1) Bismuth(3+) 2-hydroxy-1,2,3-propanetricarboxylate - (E)-N-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine (1:1:1) Ranitidine bismuth citrate Elicodil

Description	Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 3.3 μM[1]
In Vitro	Ranitidine bismuth citrate (0.1-1 μM, 5 min) is a potent irreversible inhibitor of both the ATPase (IC50=0.69 µM, Ki =0.97 µM ) and DNA-unwinding (IC50 =0.74 µM, Ki =0.39 µM) of the SARS-CoV-2 helicase[2]. Ranitidine bismuth citrate (24 hours) shows potent activity against SARS-CoV-2 with an EC50 value of 2.3 μM in Vero E6 cells[2]. Cell Cytotoxicity Assay[2] Cell Line: Monkey kidney Vero E6 cells, human colorectal Caco-2 cells Concentration: 400-3,740 μM Incubation Time: 48 hours Result: Showed low cytotoxicity with the 50% cytotoxicity concentrations (CC50) ranging from 2.2 mM and 2.5 mM.
In Vivo	Ranitidine bismuth citrate (150 mg/kg; intranasally inoculation; once daily; 4 days) suppresses SARS-CoV-2 replication, and relieves virus-associated pneumonia in a golden Syrian hamster model[2]. Ranitidine bismuth citrate (48 mg/kg, i.p.) is effective in eradicating H. pylori and H. mustelae in female ferrests with MIC values of 8 ng/L and 1-2 ng/L, respectively[3]. Ranitidine bismuth citrate (0.1 mg/kg, 0.3 mg/kg; p.o.) is effective in inhibiting gastric acid secretion and (1.0 mM) inhibits human pepsin isoenzymes activity[4]. Animal Model: Male and female Syrian hamsters (6–10 weeks)[1] Dosage: 150 mg/kg Administration: Intranasally inoculation; intraperitoneally given; once daily; 4 days Result: Suppressed SARS-CoV-2 replication, and relieved virus-associated pneumonia in a golden Syrian hamster model. Animal Model: Female Beagle dogs (14-20 kg)[3] Dosage: 0.1 mg/kg Administration: Oral dosed every hour, for 5 hours Result: Inhibited gastric acid secretion. Animal Model: Female, random-bred hooded rats (weight range 90-120 g)[4] Dosage: 0.5 mL/100 g Administration: Pre-treated with indomethacin (5 mg/kg s.c.); oral gavage Result: Inhibited gastric mucosal damage in the rat.
References	[1]. Herling AW, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb. 20(1-2):35-9. [2]. Yuan S, et al. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov. 5(11):1439-1448. [3]. Lambert JR, et al. The actions of bismuth in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther. 1997 Apr. 11(Suppl 1):27-33. [4]. Stables R, et al. Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate. Aliment Pharmacol Ther. 1993 Jun. 7(3):237-46.

Density	1.184g/cm3
Boiling Point	437.1ºC at 760mmHg
Molecular Formula	C₁₉H₂₇BiN₄O₁₀S
Molecular Weight	712.484
Flash Point	218.2ºC
Exact Mass	712.125183
PSA	252.18000
Vapour Pressure	7.66E-08mmHg at 25°C

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