130726-68-0
130726-68-0 structure
- Name: Neticonazole
- Chemical Name: 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole
- CAS Number: 130726-68-0
- Molecular Formula: C17H22N2OS
- Molecular Weight: 302.43400
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2018-02-20 08:00:00
- Modify Date: 2025-08-24 22:10:48
-
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole has anti-infection and anti-cancer effects[1][2][3].
| Name | 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole |
|---|---|
| Synonyms |
Neticonazol
Neticonazole HCl (E)-1-<2-(Methylthio)-1-<2-(pentyloxy)phenyl>ethenyl>-1H-imidazole Neticonazole Neticonazole [INN] Neticonazolum UNII-KVL61ZF9UO |
| Description | Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole has anti-infection and anti-cancer effects[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Fungal [1] Exosome secretion[2] |
| In Vitro | Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels[2]. Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells[2]. Western Blot Analysis[2] Cell Line: C4-2B cells Concentration: 10 µM Incubation Time: 48 hours Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. |
| In Vivo | Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells[3]. Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells[3] Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg Administration: Oral gavage; daily; for 15 days Result: Significantly improved the survival of IDB mice with CRC xenograft tumors. |
| References |
| Density | 1.06g/cm3 |
|---|---|
| Boiling Point | 464ºC at 760mmHg |
| Molecular Formula | C17H22N2OS |
| Molecular Weight | 302.43400 |
| Flash Point | 234.4ºC |
| Exact Mass | 302.14500 |
| PSA | 52.35000 |
| LogP | 4.66180 |
| Vapour Pressure | 8.66E-09mmHg at 25°C |
| Index of Refraction | 1.558 |