173903-47-4

173903-47-4 structure

Name: Tizoxanide
Chemical Name: 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
CAS Number: 173903-47-4
Molecular Formula: C₁₀H₇N₃O₄S
Molecular Weight: 265.245
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-12-01 09:56:16
Modify Date: 2024-01-03 16:59:14
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.IC50 value: Target: Antiviral agentin vitro: Tizoxanide inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively [2]. Nitazoxanide and its primary metabolite, tizoxanide, inhibit hepatitis C virus (HCV) replication in HCV replicon systems. Interestingly, serial passage in nitazoxanide or tizoxanide resulted in increased sensitivity to alpha interferon 2b: EC(50)s and EC(90)s were reduced three- and eightfold, respectively [3].

Name	2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Synonyms	2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide Tizoxanide Desacetylnitazoxanide Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)- Desacetyl-nitazoxanide NTZdes 2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide

Description	Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.IC50 value: Target: Antiviral agentin vitro: Tizoxanide inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively [2]. Nitazoxanide and its primary metabolite, tizoxanide, inhibit hepatitis C virus (HCV) replication in HCV replicon systems. Interestingly, serial passage in nitazoxanide or tizoxanide resulted in increased sensitivity to alpha interferon 2b: EC(50)s and EC(90)s were reduced three- and eightfold, respectively [3].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Korba BE, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63. [2]. Ashton LV, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. pii: 891010. [3]. Korba BE, et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71.