BioBioPha
China
Product Name: beta-Amyrin acetate
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: beta-Amyrin acetate
Price: ￥2358.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Olean-12-en-3-ol,3-acetate, (3b)-
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Purity: 98.0%
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1616-93-9

1616-93-9 structure

Name: beta-Amyrin acetate
Chemical Name: (4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl) acetate
CAS Number: 1616-93-9
Molecular Formula: C₃₂H₅₂O₂
Molecular Weight: 468.754
Catalog: Natural product Moss
Create Date: 2018-08-03 13:16:19
Modify Date: 2024-01-09 21:04:03
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase[1][2][3][4].

Name	(4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl) acetate
Synonyms	Olean-12-en-3β-ol, acetate (3β)-Olean-12-en-3-ylacetat Acétate de (3β)-olean-12-én-3-yle UNII:AM1H7102OC (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picenyl acetate Olean-12-en-3-ol, acetate, (3β)- AMYRIN,B Olean-12-en-3β-ol, acetate (8CI) 3-β-acetoxyolean-12-ene O-Acetyl-β-amyrin (3β)-Olean-12-en-3-yl acetate β-Amyrin acetate (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-Octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picenylacetat Olean-12-en-3-yl acetate Acétate de (3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octaméthyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picényle

Description	β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	β-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes[1]. β-Amyrin acetate (5-100 μM) has HMG-CoA reductase inhibitory activity by locating in the hydrophobic binding cleft lined with residues Leu562, Gly560, Ala564, Gly569, Ser852, Leu853, Leu857, Met854, Ala856, Ser852 and Ala855 of human HMG CoA reductase[2]. β-Amyrin acetate (7.8-1000 μg/mL, 48 h) inhibits all of the Candida fungal species tested with MIC values ranging from 30 to 250 μg/mL)[4].
In Vivo	β-Amyrin acetate (applied on the anterior surface of the right ear, 100 μg/ear, a single dose) significantly inhibits xylene-induced ear edema in mice[1]. β-Amyrin acetate (intraperitoneal injection, 4 mg/100 g, daily for 6 consecutive days) shows significant anti-inflammatory activities (43.6%) in adult albino rats[3]. β-Amyrin acetate (subcutaneous injection, 4 mg/100 g, daily for 10 days ) increases the ATP-phosphohydrolase activity in liver homogenates both in normal and arthritic rats[3]. Animal Model: Xylene-induced mouse ear topical edema model[1] Dosage: 50 and 100 μg/ear (5 μL) Administration: Applied on the anterior surface of the right ear Result: Inhibited Xylene-induced ear edema in mice Animal Model: Adult albino rats[3] Dosage: 4 mg/100g, daily for 6 consecutive days Administration: Intraperitoneal injection Result: Showed significant anti-inflammatory activities with mean average weight of granulation tissue of 9.2 mg after 6 days.
References	[1]. Nkeoma Nkasi Okoye, et al. beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity. Pharm Biol. 2014 Nov;52(11):1478-86. [2]. Ranjani Maurya, et al. β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves. Phytomedicine. 2012 Jun 15;19(8-9):682-5. [3]. M.B.Gupta, et al. Biochemical study of the anti-inflammatory activity of α and β-amyrin acetate. Biochemical Pharmacology. 1971 Feb; 2(20): 401-405. [4]. S Johann, et al. Antifungal activity of the amyrin derivatives and in vitro inhibition of Candida albicans adhesion to human epithelial cells. Lett Appl Microbiol. 2007 Aug;45(2):148-53.

Density	1.0±0.1 g/cm3
Boiling Point	505.1±49.0 °C at 760 mmHg
Molecular Formula	C₃₂H₅₂O₂
Molecular Weight	468.754
Flash Point	256.2±17.4 °C
Exact Mass	468.396729
PSA	26.30000
LogP	11.95
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.529

Hazard Codes	Xi

Precursor 0
DownStream 1
559-70-6

1616-93-9	6813-59-8
559-70-6	5973-06-8
863-76-3	6055-05-6
70801-04-6	10522-41-5
22030-19-9	10198-23-9