Name | 2-Phenylamino Adenosine |
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Synonyms | [3H]-2-Phenylaminoadenosine |
Description | CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1]. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1]. In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2]. |
In Vivo | Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3]. Animal Model: Male Sprague-Dawley rat, weighing 370-410 g[3] Dosage: 0.002, 0.02, 0.2, and 2 μM Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808 Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM. |
References |
Density | 1.78g/cm3 |
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Boiling Point | 766ºC at 760mmHg |
Melting Point | 210-212ºC |
Molecular Formula | C16H18N6O4 |
Molecular Weight | 358.35 |
Flash Point | 417.1ºC |
Exact Mass | 358.13900 |
PSA | 151.57000 |
LogP | 0.41780 |
Index of Refraction | 1.829 |
Storage condition | −20°C |
Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL |
WGK Germany | 3 |
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Precursor 7 | |
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DownStream 0 |