187986-17-0

187986-17-0 structure

Name: WKYMVm
Chemical Name: Trp-Lys-Tyr-Met-Val-D-Met
CAS Number: 187986-17-0
Molecular Formula: C₄₁H₆₁N₉O₇S₂
Molecular Weight: 856.11
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-07-31 22:13:42
Modify Date: 2025-08-26 08:21:24
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2].

Name	Trp-Lys-Tyr-Met-Val-D-Met
Synonyms	M.W. 856.11 C41H61N9O7S2 H-TRP-LYS-TYR-MET-VAL-D-MET-NH2 TRIFLUOROACETATE WKYMVMaMide,W-Peptide H-Ala-Val-Thr-Tyr-Ser-Arg-Ser-Arg-Tyr-Leu-Glu-Cys-OH Tryptophanyl-lysinyl-tyrosinyl-methionyl-valinyl-D-methionine WKYMVMAMIDE TRIFLUOROACETATE

Description	WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	FPR1, FPRL1[1], FPRL2[2]
References	[1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93. [2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.