23282-20-4

23282-20-4 structure

Name: Nivalenol
Chemical Name: nivalenol
CAS Number: 23282-20-4
Molecular Formula: C₁₅H₂₀O₇
Molecular Weight: 312.315
Catalog: analytical chemistry Standard Food and cosmetics standards
Create Date: 2018-09-25 10:25:09
Modify Date: 2024-02-04 20:55:32
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[1]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[2].

Name	nivalenol
Synonyms	Nivalenol from Fusarium nivale Trichothec-9-en-8-one, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (2α,3α,4β,6β,7β,11β,12ξ)- MFCD10567355 12,13-epoxy-3,4,7,15-tetrahydroxytrichothec-9-en-8-one Nivalenol hydrate fusarenon-X NIV Nivalenol in acetonitrile (3β,4α,7α,12ξ)-3,4,7,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one nivalenol solution

Description	Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[1]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	Caspase
References	[1]. Bryła M, et al. Natural Occurrence of Nivalenol, Deoxynivalenol, and Deoxynivalenol-3-Glucoside in Polish Winter Wheat. Toxins (Basel). 2018 Feb 13;10(2). [2]. Aupanun S, et al. Individual and combined mycotoxins deoxynivalenol, nivalenol, and fusarenon-X induced apoptosis in lymphoid tissues of mice after oral exposure. Toxicon. 2019 Jul;165:83-94.

Density	1.6±0.1 g/cm3
Boiling Point	585.1±50.0 °C at 760 mmHg
Melting Point	222-223ºC
Molecular Formula	C₁₅H₂₀O₇
Molecular Weight	312.315
Flash Point	221.9±23.6 °C
Exact Mass	312.120911
PSA	119.75000
LogP	-0.75
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.658
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0165000

CHEMICAL NAME :: Trichothec-9-en-8-one, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (3-alpha,4-beta,7-alpha)-

CAS REGISTRY NUMBER :: 23282-20-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C15-H20-O7

MOLECULAR WEIGHT :: 312.35

WISWESSER LINE NOTATION :: T C665 A AX EV IO FUTJ B1 C1Q DQ F1 KQ LQ A-& BT3OX CHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - other changes Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg/4W-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 126 mg/kg/12W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 mg/kg/26W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 262 mg/kg/1Y-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - leukopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3500 ug/kg/7D-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Skin and Appendages - hair

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 1 mg/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 24,1032,1968 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,397,1993 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,225,1974 TOXICOLOGY REVIEW NUREA8 Nutrition Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1942- Volume(issue)/page/year: 31,169,1973

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H332-H319
Precautionary Statements	P210-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+: Very toxic;Xn: Harmful;F: Flammable;
Risk Phrases	R26/27/28
Safety Phrases	S22;S26;S28;S45;S36/S37;S36/S37/S39
RIDADR	UN 2811 6
WGK Germany	3
RTECS	YD0165000
Packaging Group	I
Hazard Class	6.1(a)
HS Code	38220090

6022-19-1

23282-20-4

Literature: Lauren, Denis R.; Smith, Wendy A.; Wilkins, Alistair L. Journal of Agricultural and Food Chemistry, 1994 , vol. 42, # 3 p. 828 - 833

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