849234-64-6

849234-64-6 structure

Name: BRD-6929
Chemical Name: Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]
CAS Number: 849234-64-6
Molecular Formula: C₁₉H₁₇N₃O₂S
Molecular Weight: 351.42200
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2017-02-09 13:40:34
Modify Date: 2024-01-16 01:52:39
BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].

Name	Benzamide, 4-(acetylamino)-N-[2-amino-5-(2-thienyl)phenyl]
Synonyms	4-(acetylamino)-n-[2-amino-5-(2-thienyl)phenyl]-benzamide

Description	BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:1 nM (IC50) HDAC2:8 nM (IC50) HIV
References	[1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147 [2]. Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323. [3]. Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.