304684-77-3

304684-77-3 structure

Name: Exo2
Chemical Name: Exo2
CAS Number: 304684-77-3
Molecular Formula: C₁₈H₁₈N₄O₂S
Molecular Weight: 354.42600
Catalog: Research Areas Endocrinology
Create Date: 2017-02-06 06:13:22
Modify Date: 2025-08-25 13:06:20
Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].

Name	Exo2

Description	Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
References	[1]. Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414(3):471-84. [2]. Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355(6363):833-6.

RIDADR	NONH for all modes of transport