35899-54-8

35899-54-8 structure

Name: SIBA
Chemical Name: 5'-Isobutylthioadenosine
CAS Number: 35899-54-8
Molecular Formula: C₁₄H₂₁N₅O₃S
Molecular Weight: 339.41300
Catalog: Research Areas Others
Create Date: 2018-06-21 11:39:29
Modify Date: 2025-08-21 23:44:08
SIBA selectively inhibits spermine synthase, IC50=8 uM.IC50 value: 8 uMTarget: spermine synthaseSIBA is a powerful antiproliferative drug. SIBA has been reported to inhibit cell transformation induced by oncogenic RNA or DNA viruses, the growth of transformed mouse mammary cells, the mitogen-stimulated blastogenesis of lymphocytes and the capping of herpes virus mRNA 161. It has also been demonstrated that an antimalarial activity is exerted by SIBA against Plasmodium falciparum in cultures.

Name	5'-Isobutylthioadenosine
Synonyms	adenosine,5'-s-(2-methylpropyl)-5'-thio- 5-isobutylthio-5-deoxyadenosine SIBA

Description	SIBA selectively inhibits spermine synthase, IC50=8 uM.IC50 value: 8 uMTarget: spermine synthaseSIBA is a powerful antiproliferative drug. SIBA has been reported to inhibit cell transformation induced by oncogenic RNA or DNA viruses, the growth of transformed mouse mammary cells, the mitogen-stimulated blastogenesis of lymphocytes and the capping of herpes virus mRNA 161. It has also been demonstrated that an antimalarial activity is exerted by SIBA against Plasmodium falciparum in cultures.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Carteni-Farina M, et al. Studies on the metabolism of 5'-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270. [2]. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%