87377-08-0

87377-08-0 structure

Name: Indomethacin-D4
Chemical Name: 1-(-p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid-d4
CAS Number: 87377-08-0
Molecular Formula: C₁₉H₁₂D₄ClNO₄
Molecular Weight: 361.81200
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2016-06-28 21:46:29
Modify Date: 2024-01-23 16:54:06
Indomethacin-D4 (Indometacin-D4) is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1].

Name	1-(-p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid-d4

Description	Indomethacin-D4 (Indometacin-D4) is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	Human COX-1:18 nM (IC50, in CHO cells) Human COX-2:26 nM (IC50, in CHO cells)
References	[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.