358-52-1

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C10-H15-N-O2

MOLECULAR WEIGHT :

181.26

WISWESSER LINE NOTATION :

L6TJ AOVZ A2UU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

800 mg/kg

TOXIC EFFECTS :

Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :

MTAEEB Medical Toxicology and Adverse Drug Experience. (Adis International Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.) V.4- 1989- Volume(issue)/page/year: 4,295,1989

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

228 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,1593,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

286 mg/kg/36H-I

TOXIC EFFECTS :

Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

MTAEEB Medical Toxicology and Adverse Drug Experience. (Adis International Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.) V.4- 1989- Volume(issue)/page/year: 4,295,1989

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,414,1972

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

450 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,414,1972