514-62-5

514-62-5 structure

Name: (+)-ferruginol
Chemical Name: ferruginol
CAS Number: 514-62-5
Molecular Formula: C₂₀H₃₀O
Molecular Weight: 286.452
Catalog: Natural product Moss
Create Date: 2017-11-06 13:40:06
Modify Date: 2024-01-07 16:51:02
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial Apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].

Name	ferruginol
Synonyms	3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Abieta-9(11),8(14),12-trien-12-ol Abieta-8,11,13-triene-12-ol Ferruginol (4bS,8aS)-2-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydro-phenanthren-3-ol Abieta-8,11,13-trien-12-ol

Description	Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial Apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Cardiovascular Disease Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Ferruginol（0-160 μM；24 小时）对甲状腺癌细胞具有有效的抗增殖作用，对 MDA-T32 细胞系的 IC50 为 12 μM。Ferruginol 对正常细胞的毒性作用不太明显[1]。 Ferruginol（0-24 μM；24 小时）诱导 MDA-T32 细胞的凋亡性细胞死亡。Ferruginol 剂量依赖性地增加 Bax 表达并降低 Bcl-2 表达[1]。 Ferruginol（0-24 μM；24 小时）抑制 MDA-T32 细胞的 MAPK 和 PI3K/AKT 信号通路[1]。 Ferruginol（0-24 μM；24 小时）还会引起 ROS 介导的 MDA-T32 细胞基质金属蛋白酶改变[1]。 Cell Viability Assay[1] Cell Line: MDA-T32 cells Concentration: 0-160 μM Incubation Time: 24 hours Result: Exerted potent antiproliferative action against thyroid cancer cells. Apoptosis Analysis[1] Cell Line: MDA-T32 cells Concentration: 0 μM, 6 μM, 12 μM, and 24 μM Incubation Time: 24 hours Result: Induced apoptotic cell death of MDA-T32 cells Western Blot Analysis[1] Cell Line: MDA-T32 cells Concentration: 0 μM, 6 μM, 12 μM, and 24 μM Incubation Time: 24 hours Result: Blocked the MAPK and PI3K/AKT signaling pathway.
In Vivo	Ferruginol（20 mg/kg；口服；每天；持续 4 周）发挥心脏保护作用，表现为增强的心脏功能和减少的结构损伤和细胞凋亡。转录组和其他结果表明，Ferruginol 通过增加 PGC-1α 的表达并同时促进 SIRT1 增强脱乙酰酶 SIRT1 去乙酰化和激活 PGC-1α 的表达，促进 PGC-1α 介导的线粒体生物发生和脂肪酸氧化 (MB 和 FAO)[3]。 Animal Model: Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)[3]. Dosage: 20 mg/kg Administration: Administered intragastrically; daily; for 4 weeks Result: Relieved Doxorubicin-induced cardiac structural and functional lesion.
References	[1]. Guoqing Luo, et al. Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways. Med Sci Monit. 2019 Apr 21;25:2935-2942. [2]. Weili Li, et al. Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity. Front Pharmacol. 2021 Nov 24;12:773834. [3]. Manabu Iwamoto, et al. Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii. Planta Med. 2003 Jan;69(1):69-72.

Density	1.0±0.1 g/cm3
Boiling Point	388.1±31.0 °C at 760 mmHg
Melting Point	56-57℃
Molecular Formula	C₂₀H₃₀O
Molecular Weight	286.452
Flash Point	175.1±14.5 °C
Exact Mass	286.229675
PSA	20.23000
LogP	7.57
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.530

Precursor 0
DownStream 3
483-87-4 6314-07-4 832-69-9

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