483-53-4

483-53-4 structure

Name: 3,4,5-trihydroxy-6-methylphthalaldehyde
Chemical Name: 3,4,5-trihydroxy-6-methylphthalaldehyde
CAS Number: 483-53-4
Molecular Formula: C₉H₈O₅
Molecular Weight: 196.15700
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2017-06-10 15:04:10
Modify Date: 2025-08-27 17:23:19
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2].

Name	3,4,5-trihydroxy-6-methylphthalaldehyde
Synonyms	1,2-Benzenedicarboxaldehyde,3,4,5-trihydroxy-6-methyl 3,4,5-Trihydroxy-6-methyl-1,2-benzenedicarboxaldehyde Phthalaldehyde,3,4,5-trihydroxy-6-methyl

Description	Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Inflammation/Immunology
References	[1]. "Alzahrani A, et al. Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis. Saudi Pharm J. 2020;28(12):1605-1615. " [2]. Li H, et al. Polyketides from two Chaetomium species and their biological functions. J Antibiot (Tokyo). 2018;71(7):677-681.