848353-85-5

848353-85-5 structure

Name: Fluorofenidone
Chemical Name: 1-(3-fluorophenyl)-5-methylpyridin-2-one
CAS Number: 848353-85-5
Molecular Formula: C₁₂H₁₀FNO
Molecular Weight: 203.21200
Catalog: Signaling Pathways Others Others
Create Date: 2016-11-20 07:02:53
Modify Date: 2025-08-25 06:31:16
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

Name	1-(3-fluorophenyl)-5-methylpyridin-2-one
Synonyms	fluorofenidone

Description	Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
Related Catalog	Signaling Pathways >> Others >> Others
References	[1]. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. [2]. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.