1246833-26-0

1246833-26-0 structure

Name: Curcumin D6
Chemical Name: (1E,6E)-1,7-bis[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,6-diene-3,5-dione
CAS Number: 1246833-26-0
Molecular Formula: C₂₁H₁₄D₆O₆
Molecular Weight: 374.41700
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2017-05-04 05:33:02
Modify Date: 2024-01-20 17:14:09
Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

Name	(1E,6E)-1,7-bis[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,6-diene-3,5-dione
Synonyms	Halad-d6 Haidr-d6 Diferuloylmethane-d6 Curcumine-d6 Curcuma-d6 Ukon-d6 Haldar-d6 Curcumin-d6 C Yellow 15-d6

Description	Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Infection Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Metabolic Disease Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
References	[1]. Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004. [2]. Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53. [3]. Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4. [4]. Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4. [5]. Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303.

Molecular Formula	C₂₁H₁₄D₆O₆
Molecular Weight	374.41700
Exact Mass	374.16400
PSA	93.06000
LogP	3.36990

Hazard Codes	Xi

1335198-02-1	1246833-26-0
890984-26-6	2171091-50-0
387818-26-0	1529769-81-0
458-37-7	227466-72-0
339286-19-0	19697-86-0