54280-71-6
54280-71-6 structure
- Name: Nemadipine-A
- Chemical Name: diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CAS Number: 54280-71-6
- Molecular Formula: C19H18F5NO4
- Molecular Weight: 419.34300
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2016-07-13 23:33:49
- Modify Date: 2024-01-02 13:47:24
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Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].
| Name | diethyl 2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
|---|---|
| Synonyms |
HMS3262D09
2,6-dimethyl-4-pentafluorophenyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester Diethyl-4-(2,3,4,5,6-pentafluoro)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Nemadipine-A |
| Description | Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (µM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants[1]. Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin[2]. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity[2]. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death[2]. Cell Viability Assay[2] Cell Line: H1299 lung adenocarcinoma cells Concentration: 0, 5, 10, 20, and 30 μM Incubation Time: 8 hours Result: H1299 cells were resistant to the apoptotic effects of TRAIL, but the co-administration of Nemadipine-A and TRAIL in these cells resulted in notably increased cytotoxicity in a dose-dependent manner. Western Blot Analysis[2] Cell Line: H1299 cells Concentration: 20 μM Incubation Time: 8 hours Result: Co-treated with TRAIL and Nemadipine-A (T/N; 20 ng/mL and 20 μM respectively) induced cell death in H1299 cells. |
| References |
| Molecular Formula | C19H18F5NO4 |
|---|---|
| Molecular Weight | 419.34300 |
| Exact Mass | 419.11600 |
| PSA | 64.63000 |
| LogP | 4.07190 |
|
~92%
54280-71-6 |
| Literature: Sharma, Mukul; Agarwal, Nisha; Rawat, Diwan S. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 3 p. 737 - 739 |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |