139726-30-0

139726-30-0 structure

Name: Isodunnianol
Chemical Name: 5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol
CAS Number: 139726-30-0
Molecular Formula: C₂₇H₂₆O₃
Molecular Weight: 398.493
Catalog: Natural product Lignans
Create Date: 2017-03-05 08:14:13
Modify Date: 2024-01-14 20:31:52
Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1].

Name	5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol
Synonyms	Isodunnianol 12-Hydroxy-drim-8-en-11-saeure-lacton 12-hydroxy-drim-8-en-11-oic acid-lactone 5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol Isodrimenin isoduinnianol [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-3-[4-(2-propen-1-yl)phenoxy]- MEGPFBRAROUGQD-NHYWBVRUSA Isodrimenine

Description	Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Isodunnianol (10 µM; 6, 24 h) 在 H9C2 细胞中诱导自噬并增加 pAMPK172、pULK1555 的表达，降低 pULK1757、SQSTM2 的表达[1]。 Cell Autophagy Assay[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Induced autophagic. Western Blot Analysis[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Significantly increased the expression of pAMPK172, pULK1555,decreased teh expression of pULK1757, SQSTM2 in a time-dependent manner.
References	[1]. Chen C , et al . Isodunnianol alleviates duxorubicin-induced myocardial injury by activating protective autophagy. Food Funct. 2019 May 22;10(5):2651-2657.

Hazard Codes	Xi