90729-42-3
90729-42-3 structure
- Name: Carebastine
- Chemical Name: 2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid
- CAS Number: 90729-42-3
- Molecular Formula: C32H37NO4
- Molecular Weight: 499.641
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2018-09-05 18:42:05
- Modify Date: 2024-01-02 23:31:17
-
Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
| Name | 2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid |
|---|---|
| Synonyms |
p-(4-(4-(Diphenylmethoxy)piperidino)butyryl)-a-methylhydratropic Acid
Carebastinum carebastine 2-(4-{4-[4-(Diphenylmethoxy)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid 4-(4-(4-(Diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-a,a-dimethylbenzeneacetic Acid Benzeneacetic acid, 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl- Carebastina C32H37NO4 UNII-75DLN707DO 2-(4-{4-[4-(Diphenylmethoxy)-1-piperidinyl]butanoyl}phenyl)-2-methylpropanoic acid |
| Description | Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2]. |
|---|---|
| Related Catalog | |
| Target |
H1 receptor |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 657.9±55.0 °C at 760 mmHg |
| Melting Point | 178-180ºC |
| Molecular Formula | C32H37NO4 |
| Molecular Weight | 499.641 |
| Flash Point | 351.7±31.5 °C |
| Exact Mass | 499.272247 |
| PSA | 66.84000 |
| LogP | 6.09 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.609 |