Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-(4-(4-(4-(BENZHYDRYLOXY)PIPERIDIN-1-YL)BUTANOYL)PHENYL)-2-METHYLPROPANOIC ACID
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Purity: 98.0%
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90729-42-3

90729-42-3 structure

Name: Carebastine
Chemical Name: 2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid
CAS Number: 90729-42-3
Molecular Formula: C₃₂H₃₇NO₄
Molecular Weight: 499.641
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-09-05 18:42:05
Modify Date: 2025-08-23 10:28:07
Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].

Name	2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid
Synonyms	p-(4-(4-(Diphenylmethoxy)piperidino)butyryl)-a-methylhydratropic Acid Carebastinum carebastine 2-(4-{4-[4-(Diphenylmethoxy)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid 4-(4-(4-(Diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-a,a-dimethylbenzeneacetic Acid Benzeneacetic acid, 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl- Carebastina C32H37NO4 UNII-75DLN707DO 2-(4-{4-[4-(Diphenylmethoxy)-1-piperidinyl]butanoyl}phenyl)-2-methylpropanoic acid

Description	Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 receptor
References	[1]. De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34(4):958-66. [2]. Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33(6):785-7.