16860-43-8
16860-43-8 structure
- Name: 3,5-Pyrazolidinedione,4-butyl-4-hydroxy-1,2-diphenyl-
- Chemical Name: 4-Hydroxy Phenylbutazone
- CAS Number: 16860-43-8
- Molecular Formula: C19H20N2O3
- Molecular Weight: 324.37400
- Catalog: Research Areas Others
- Create Date: 2017-06-02 19:06:51
- Modify Date: 2025-09-20 20:09:29
-
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS)[1].
| Name | 4-Hydroxy Phenylbutazone |
|---|---|
| Synonyms |
4-Butyl-4-hydroxy-1,2-diphenyl-3,5-pyrazolidinedione 4-Hydroxyphenylbutazone
4-butyl-4-hydroxy-1,2-diphenylpyrazolidine-3,5-dione Phenylbutazone impurity B |
| Description | 4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 4-hydroxyphenylbutazone is isolated from incubations of phenylbutazone with either ram seminal vesicle microsomes or horseradish peroxidase. 4-hydroxyphenylbutazone is ineffective inhibitor of PHS cyclooxygenase[1]. |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 462.3ºC at 760mmHg |
| Molecular Formula | C19H20N2O3 |
| Molecular Weight | 324.37400 |
| Flash Point | 233.4ºC |
| Exact Mass | 324.14700 |
| PSA | 60.85000 |
| LogP | 3.03270 |
| Vapour Pressure | 2.41E-09mmHg at 25°C |
| Index of Refraction | 1.615 |
| HS Code | 2933990090 |
|---|
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |