522-51-0

522-51-0 structure

Name: Dequalinium Chloride
Chemical Name: dequalinium chloride
CAS Number: 522-51-0
Molecular Formula: C₃₀H₄₀Cl₂N₄
Molecular Weight: 527.571
Catalog: API Synthetic anti-infective drugs Disinfectant antiseptic
Create Date: 2018-05-22 08:00:00
Modify Date: 2024-01-02 14:50:08
Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2].

Name	dequalinium chloride
Synonyms	Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride DECA efisol dekamin evazol le chlorure de dequalinium dekadin EINECS 208-330-9 1,1'-Decan-1,10-diylbis(4-amino-2-methylchinolinium)dichlorid BADQ-10 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium) dichloride dequadin eriosept 1,1'-Decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride Dequalinium Chloride dequavet baqd10 Dequadin chloride Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2) MFCD00063502 Dequalinium (Chloride)

Description	Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Infection
References	[1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10. [2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5.

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 82,231,1993

Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VA0700000
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%