168560-79-0

168560-79-0 structure

Name: AIDA
Chemical Name: (RS)-1-Aminoindan-1,5-dicarboxylicacid
CAS Number: 168560-79-0
Molecular Formula: C₁₁H₁₁NO₄
Molecular Weight: 221.20900
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-01-01 08:24:11
Modify Date: 2024-01-08 00:02:35
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].

Name	(RS)-1-Aminoindan-1,5-dicarboxylicacid
Synonyms	1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23 MFCD00672638 (R,S)-1-Aminoindane-1,5 Valerenic acid 1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid,1-Aminoindan-1,5-dicarboxylic acid

Description	UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR
Target	mGluR1a:214 μM (IC50)
In Vivo	UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1]. Animal Model: Naive male hooded Lister rats (320–350 g)[1] Dosage: 0.18 mg/kg Administration: I.p.; 0.5 ml per 100 g Result: Showed no gross motor abnormalities and normal righting reflexes.
References	[1]. Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326(2-3):105-108. [2]. Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1(2):151-161.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39
RIDADR	NONH for all modes of transport
HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%