55749-97-8

55749-97-8 structure

Name: Litorin
Chemical Name: Litorin
CAS Number: 55749-97-8
Molecular Formula: C₅₁H₆₈N₁₄O₁₁S
Molecular Weight: 1085.24
Catalog: Signaling Pathways GPCR/G Protein Bombesin Receptor
Create Date: 2018-10-12 14:48:42
Modify Date: 2025-08-23 12:18:54
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].

Name	Litorin
Synonyms	5-Oxo-L-Pro-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2 Efonidipine hydrochloride monoethanolate M.W. 1084.47 C51H68N14O11S pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 2-De-L-Val-3-de-L-Pro-ranatensin Pituitary adenylate cyclase activating fragment 21-38 pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2,Pituitary adenylate cyclase activating fragment 21-38 GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 PYR-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2

Description	Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
In Vitro	99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R)[1]. [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM[2]. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM[2].
In Vivo	Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments[2].
References	[1]. Kam Leung. ^99mTc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. Molecular Imaging and Contrast Agent Database (MICAD). 2007 Oct 1. [2]. J M Siegfried, et al. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 1993 May;236(1):241-7.