Name | cinalukast |
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Synonyms |
Cinalukast
4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid |
Description | Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. |
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Related Catalog | |
Target |
IC50: 6.4 nM (LTD4)[1] |
In Vitro | Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1]. |
In Vivo | Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1]. Animal Model: Guinea pigs[1] Dosage: 10 mg/kg Administration: Oral gavage; 10 mg/kg once Result: Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs. |
Density | 1.258g/cm3 |
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Molecular Formula | C23H28N2O3S |
Molecular Weight | 412.54500 |
Exact Mass | 412.18200 |
PSA | 107.53000 |
LogP | 5.87360 |
Index of Refraction | 1.655 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |