101189-47-3

101189-47-3 structure

Name: CP-66948
Chemical Name: 1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
CAS Number: 101189-47-3
Molecular Formula: C₁₃H₂₀N₆S
Molecular Weight: 292.40300
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2016-11-15 02:50:51
Modify Date: 2024-01-02 15:22:48
CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.

Name	1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
Synonyms	2-(N-Pentyl-N''-guanidino)-4-(2-methylimidazol-4-yl)thiazole CP-66,948 Guanidine,N-(4-(2-methyl-1H-imidazol-4-yl)-2-thiazolyl)-N'-pentyl CP-66948

Description	CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Others
In Vivo	The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously)[1].
References	[1]. Hakkinen JP, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8.