128470-16-6

128470-16-6 structure

Name: Arbutamine
Chemical Name: arbutamine
CAS Number: 128470-16-6
Molecular Formula: C₁₈H₂₃NO₄
Molecular Weight: 317.38000
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-06-24 22:39:09
Modify Date: 2025-08-21 21:41:01
Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].

Name	arbutamine
Synonyms	4-[(1R)-1-Hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]-1,2-b enzenediol

Description	Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β-adrenoceptor[1]
In Vivo	Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).
References	[1]. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70. [2]. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.