366495-94-5

366495-94-5 structure

Name: 16b-Hydroxyestradiol
Chemical Name: 16beta-hydroxy-17beta-estradiol-2,4-d2
CAS Number: 366495-94-5
Molecular Formula: C₁₈H₂₂D₂O₃
Molecular Weight: 290.39
Create Date: 2018-06-11 19:06:22
Modify Date: 2025-08-22 19:52:11
16β-Hydroxy-17β-estradiol-2,4-d2 is the deuterium labeled 16β-Hydroxy-17β-estradiol-2,4[1].

Name	16beta-hydroxy-17beta-estradiol-2,4-d2
Synonyms	D1,3,5-Estratriene-3,16b,17b-triol 16-Epioestriol Estra-1,3,5(10)-triene-3,16β,17β-triol (16β,17β)-Estra-1,3,5(10)-triene-3,16,17-triol (16b,17b)-Estra-1,3,5(10)-triene-3,16,17-triol Estra-1,3,5(10)-triene-3,16b,17b-triol Actriol 16b,17b-Estriol 16β,17β-Estriol epiestriol Estra-1,3,5(10)-triene-3,16,17-triol, (16β,17β)-

Description	16β-Hydroxy-17β-estradiol-2,4-d2 is the deuterium labeled 16β-Hydroxy-17β-estradiol-2,4[1].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Brinton LA, et al. Serum Estrogens and Estrogen Metabolites and Endometrial Cancer Risk among Postmenopausal Women. Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1081-9. [3]. Skariyachan S, et al. Natural epiestriol-16 act as potential lead molecule against prospective molecular targets of multidrug resistant Acinetobacter baumannii-Insight from in silico modelling and in vitro investigations. Infect Genet Evol. 2020 Aug;82:104314. [4]. Latman NS, et al. 16-epiestriol: an anti-inflammatory steroid without glycogenic activity. J Pharm Sci. 1994 Jun;83(6):874-7.