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116229-36-8

116229-36-8 structure
116229-36-8 structure
  • Name: Bactenecin
  • Chemical Name: bactenecin
  • CAS Number: 116229-36-8
  • Molecular Formula: C63H118N24O13S2
  • Molecular Weight: 1483.89000
  • Catalog: Peptides
  • Create Date: 2017-03-04 04:52:31
  • Modify Date: 2024-01-02 15:02:25
  • Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.
Name bactenecin
Synonyms R-lactic acid tert-butyl ester
bovine dodecapeptide
D-lactic acid tert-butyl ester
RLCRIVVIRVCR 3-11 disulfide
Description Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.
Related Catalog
Target

Bacterial, Fungal[1]
In Vitro Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum. Acetylation and amidation of the amino- and carboxy-termini of bactenecin do not change its potency, while replacement of its two cysteine residues with serine decreases the potency[1]. Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells. This neurotoxicity is unique to bactenecin, as a panel of antibacterial peptides from vertebrates and invertebrates, like defensins corticostatin, indolicidin, cecropin P1, tachyplesin I, the magainins, or apidaecins did not impair neuronal viability[2].
Cell Assay Rat neuronal cells (5000 cells/well) are incubated for 24 hr with bactenecin (0.3, 0.6, 1.25, 2.5, 5, 10, 20, 40 μg/mL) or the control peptide. Cytotoxicity is assayed in 96-well tissue culture plates using a commercially available kit. The method is based on cellular reduction of tetrazolium salt into intensely coloured formazan derivates.[2].
References

[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46.

[2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62.
Density 1.43g/cm3
Molecular Formula C63H118N24O13S2
Molecular Weight 1483.89000
Exact Mass 1482.88000
PSA 681.62000
LogP 5.55260
Index of Refraction 1.649
Storage condition 2-8℃
Precursor  4

DownStream  0


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title: CAS No. 116229-36-8 | Chemsrc address: https://www.chemsrc.com/en/baike/523805.html

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