116409-29-1

116409-29-1 structure

Name: NSC 370284
Chemical Name: 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
CAS Number: 116409-29-1
Molecular Formula: C₂₁H₂₅NO₆
Molecular Weight: 387.42600
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2017-12-29 10:28:05
Modify Date: 2025-08-27 18:48:03
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. NSC-370284 has low cytotoxicity[1].

Name	6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol

Description	NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. NSC-370284 has low cytotoxicity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	STAT3 STAT5 TET1
In Vitro	NSC-370284 (0-500 nM；24 h 或 48 h) 通过靶向 STAT3/5 抑制 MONOMAC-6、THP-1、KOCL-48 和 KASUMI-1 急性髓系白血病 (AML) 细胞活力。NSC-370284 显著下调 TET1 转录水平[1]。 Cell Viability Assay[1] Cell Line: AML cell lines including MONOMAC-6, THP-1, KOCL-48, and KASUMI-1 Concentration: 0, 25, 50, 200 or 500 nM Incubation Time: 24 h or 48 h Result: Showed inhibitory for AML cells viability and TET1 transcription.
In Vivo	NSC-370284 (2.5 mg/kg；腹腔注射，每天一次，持续 10 天) 改善了 MLL-AF9 急性髓系白血病 (AML) 小鼠模型外周血 (PB)、骨髓 (BM)、脾和肝组织的病理形态学[1]。 Animal Model: C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1]. Dosage: 2.5 mg/kg. Administration: Intraperitoneal injection, once daily, for 10 days. Result: Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.
References	[1]. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.

123-75-1

533-31-3

86-81-7

~90%

116409-29-1

Literature: Journal of Heterocyclic Chemistry, , vol. 25, # 1 p. 89 - 96