64862-96-0

64862-96-0 structure

Name: Ametantrone
Chemical Name: 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
CAS Number: 64862-96-0
Molecular Formula: C₂₂H₂₈N₄O₄
Molecular Weight: 412.482
Create Date: 2018-09-28 13:14:25
Modify Date: 2024-01-21 12:01:22
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break[1].

Name	1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
Synonyms	9,10-ANTHRACENEDIONE, 1,4-BIS((2-((2-HYDROXYETHYL)AMINO)ETHYL)AMINO)- 9,10-Anthracenedione, 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- Ametantrone 1,4-Bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthraquinone

Description	Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83(9):1208-1216.

CHEMICAL NAME :: Anthraquinone, 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-

TOXIC EFFECTS :: Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 47,73,1985

HS Code	2922509090

28736-42-7

111-41-1

~36%

64862-96-0

141-43-5

111228-28-5

~84%

64862-96-0

Literature: Dzieduszycka; Stefanska; Kolodziejczyk; Borowski; Martelli Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 219 - 226

4471-41-4

64862-96-0

Literature: Dzieduszycka; Stefanska; Kolodziejczyk; Borowski; Martelli Farmaco, Edizione Scientifica, 1987 , vol. 42, # 3 p. 219 - 226

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%