671-88-5

671-88-5 structure

Name: Desamide
Chemical Name: 4-chloro-6-methylbenzene-1,3-disulfonamide
CAS Number: 671-88-5
Molecular Formula: C₇H₉ClN₂O₄S₂
Molecular Weight: 284.74000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2018-07-08 19:54:38
Modify Date: 2024-01-16 14:52:00
Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1].

Name	4-chloro-6-methylbenzene-1,3-disulfonamide
Synonyms	Diuroblitz 5-chloro-toluene-2,4-disulfonic acid diamide Edemil Desamide Tolclotidum Disulphamide 5-Chlor-toluol-2,4-disulfonsaeure-diamid Toluidrin 6-Chlor-4-methyl-benzol-1,3-disulfonsaeurediamid 5-Chlor-toluol-2,4-disulfonamid Disamide Toluren Ethacrynic acid Disulfamide Fisiuretik

Description	Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Metabolic Disease
Target	IC50: 0.07 μM (carbonic anhydrase)[1]
In Vivo	Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats[2]. Animal Model: Male Wistar rats weighing between 200-300 g[2] Dosage: 200 mg/kg Administration: Intraperitoneal injection; once Result: Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.
References	[1]. CT Supuran, et al. Carbonic anhydrase inhibitors: Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. European Journal of Medicinal Chemistry,Volume 31, Issue 11, 1996, Pages 843-846. [2]. J M Foy, et al. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897-902.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(4),134S,1960

13940-86-8

671-88-5

Literature: de Stevens et al. Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 565,573

108-41-8

671-88-5

Literature: de Stevens et al. Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 565,573

Precursor 1
108-41-8
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