130-37-0

130-37-0 structure

Name: Menadione sodiuM bisulfite
Chemical Name: menadione sodium sulfonate
CAS Number: 130-37-0
Molecular Formula: C₁₁H₉NaO₅S
Molecular Weight: 276.241
Catalog: API Vitamins and minerals Vitamin C drugs
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-08 16:17:38
Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

Name	menadione sodium sulfonate
Synonyms	hemodal menadione sodium bisulfite sodium 2-methyl-1,2,3,4-tetrahydronaphthalene-1,4-dione-2-sulfonate kawitan golagenk kavitan UNII:97K34V88SA msbc 2-Methyl-1,4-naphthoquinone sodium bisulfite EINECS 204-987-0 Sodium 1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonate sodium 2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonate Sodium 2-methyl-1,4-dioxo-1,2,3,4-tetrahydro-2-naphthalenesulfonate MENADIONE SODIUM SULFONATE kalzon ido-k MFCD00051456 2-Naphthalenesulfonic acid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt (1:1) bisulfite sodique de menadione klotogen hykinone vikasol hemoklot menadioni natrii bisulfis bisulfito sodico de menadiona

Description	Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection
In Vitro	Menadione sodium bisulfite (500 μM) treatment and the concomitant ROS increase have an important impact on the photosynthetic activity of the cells. Global and specific antioxidant defences decrease with Menadione sodium bisulfite (500 μM) treatment[1]. Menadione sodium bisulfite and PABA activate similar defense responses (PR, ROS, and HR). Menadione sodium bisulfite enhances resistance, both locally and systemically, to phoma stem canker disease caused by Leptosphaeria maculans. Menadione sodium bisulfite treatment induces resistance against downy mildew in pearl millet. Menadione sodium bisulfite acts through priming of specific sets of the plant innate-defense repertoire. Menadione sodium bisulfite treatment up-regulates the expression of a gene encoding a GRX480 protein, a member of the glutaredoxin family that regulates protein redox state[1].
Kinase Assay	Briefly, cells are lysed by sonication (6 cycles of 10 s separated by 30 s, on ice) in a buffer containing 25 mM Hepes at pH 7.5, 5 mM MgCl2, 5 mM DTT, 2 mM PMSF, 5 mM EDTA, 400 mM sorbitol and 10 μg/mL Protease Inhibitor cocktail. A quantity of 40 μg Symbiodinium protein extract is incubated in the reaction buffer. The mixture consists of 50 μM Ac-DEVD-AFC, 100 mM Hepes at pH 7.5, 10% (v/v) sucrose, 0.1% (v/v) CHAPS, 10 mM DTT and 10 mM PMSF. Samples are then incubated in black 96-well microplates and the fluorescence emitted is measured every 3 min for 90 min at 505 nm, with a 400 nm excitation wavelength provided by a FLX-Xenius spectrofluorometer. Caspase-like activities are then expressed in pmol of AFC cleavage per minute and illustrated as percentage of the controls.
References	[1]. Roberty S, et al. Differential antioxidant response between two Symbiodinium species from contrasting environments. Plant Cell Environ. 2016 Dec;39(12):2713-2724.

Melting Point	121-124ºC
Molecular Formula	C₁₁H₉NaO₅S
Molecular Weight	276.241
Exact Mass	276.006836
PSA	99.72000
LogP	1.84040
Storage condition	−20°C
Water Solubility	H2O: ≥50mg/mL, clear, colorless to faintly yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK3682000

CHEMICAL NAME :: 2-Naphthalenesulfonic acid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt

CAS REGISTRY NUMBER :: 130-37-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C11-H9-O5-S.Na

MOLECULAR WEIGHT :: 276.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg/9D-I

TOXIC EFFECTS :: Cardiac - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 25 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 41,1283,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84777 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 705 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84777 No. of Facilities: 524 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2658 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H315-H319-H410
Precautionary Statements	P273-P305 + P351 + P338-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
Hazard Class	9.0
HS Code	2914700090

58-27-5

130-37-0

Literature: Russian Journal of Applied Chemistry, , vol. 74, # 3 p. 469 - 472

91-57-6

~17%

130-37-0

Literature: AIR WATER CHEMICAL INC Patent: JP2005/187414 A, 2005 ; Location in patent: Page/Page column 5-6 ;

Precursor 2
58-27-5 91-57-6
DownStream 1
58-27-5

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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