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33402-03-8

33402-03-8 structure
33402-03-8 structure
Name metaraminol bitartrate
Synonyms (-)-α-(1-Aminoethyl)-m-hydroxybenzyl alcohol tartrate (1:1) (salt)
2-Amino-1-(m-hydroxyphenyl)-1-propanol Bitartrate
Aramine
m-Hydroxyphenylpropanolamine Bitartrate
(-)-a-(1-Aminoethyl)-m-hydroxybenzyl Alcohol Tartrate (1:1) (salt)
Metaraminol bitartrate
Pressorol
Metaradrine Bitartrate
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (αR)-α-[(1S)-1-aminoethyl]-3-hydroxybenzenemethanol (1:1)
MFCD00238763
a-(m-Hydroxyphenyl)-b-aminopropanol Bitartrate
m-Hydroxynorephedrine Bitartrate
1-(m-Hydroxyphenyl)-2-amino-1-propanol Bitartrate
l-Metaraminol Bitartrate
(2R,3R)-2,3-Dihydroxysuccinic acid - 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol (1:1)
(-)-erythro-Metaraminol Bitartrate
[R-(R*,S*)]-a-(1-Aminoethyl)-3-hydroxybenzenemethanol Bitartrate
Metaraminol (+)-bitartrate salt
EINECS 251-502-3
m-Hydroxypropadrine Bitartrate
3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol 2,3-dihydroxybutanedioate (1:1)
m-Hydroxy-a-(1-aminoethyl)benzyl Alcohol Bitartrate
Metaraminol (tartrate)
Boiling Point 357.9ºC at 760 mmHg
Molecular Formula C13H19NO8
Molecular Weight 317.292
Flash Point 170.3ºC
Exact Mass 317.111053
PSA 181.54000

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DN5160000
CAS REGISTRY NUMBER :
33402-03-8
LAST UPDATED :
199712
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C9-H13-N-O2.C4-H6-O6
MOLECULAR WEIGHT :
317.33
WISWESSER LINE NOTATION :
ZY&YQR CQ &622 &QVYQYQVQ &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3427 ug/kg
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,89,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
99 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 15,304,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5326 No. of Facilities: 75 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 5755 (estimated) No. of Female Employees: 5216 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311 + H331
Precautionary Statements P261-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R23/24/25
Safety Phrases S26-S28-S36/37/39-S45
RIDADR UN 2811
WGK Germany 3
RTECS DN5160000
HS Code 2922509090
HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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