Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-hydroxystearic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

3384-24-5

3384-24-5 structure

3384-24-5 structure

Name: 9-hydroxystearic acid
Chemical Name: 9-hydroxyoctadecanoic acid
CAS Number: 3384-24-5
Molecular Formula: C₁₈H₃₆O₃
Molecular Weight: 300.48
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2017-02-26 04:41:55
Modify Date: 2024-02-02 17:55:19
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].

Name	9-hydroxyoctadecanoic acid
Synonyms	9-hydroxy-octadecanoic acid 9-hydroxyoctadexanoic acid 9-HSA (+/-)-9-hydroxy-octadecanoic acid (+/-)-9-Hydroxy-octadecansaeure 9-hydroxystearic acid

Description	9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1
In Vitro	9-Hydroxyoctadecanoic acid (9-HSA) 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 9-Hydroxyoctadecanoic acid (9-HSA) (100 μM; 24 h) 抑制 HT29 细胞增殖，诱导 G0/G1 阻滞，并在转录和翻译水平上增加 p21WAF1 表达[2]。 Cell Proliferation Assay9-Hydroxyoctadecanoic acid 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 Cell Line: HT29 cell Concentration: 100 μM Incubation Time: 24 h Result: Resulted in a significant inhibition of cell proliferation. Cell Cycle Analysis9-Hydroxyoctadecanoic acid 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 Cell Line: HT29 cell Concentration: 100 μM Incubation Time: 24 h Result: Decreased S-phase activity by 50.2% compared with untreated controls, and the growth inhibition was associated with a strong arrest in G0/G1. Western Blot Analysis9-Hydroxyoctadecanoic acid 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 Cell Line: HT29 cell Concentration: 100 μM Incubation Time: 24 h Result: Increased the expression of p21WAF1. RT-PCR9-Hydroxyoctadecanoic acid 可以结合到人 HDAC1 蛋白三维模型的活性位点[1]。 Cell Line: HT29 cell Concentration: 100 μM Incubation Time: 24 h Result: Induced p21WAF1 tanscript.
References	[1]. Calonghi N, et al. Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. J Lipid Res. 2005 Aug;46(8):1596-603. [2]. Calonghi N, et al. 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. Biochem Biophys Res Commun. 2004 Jan 30;314(1):138-42.

Molecular Formula	C₁₈H₃₆O₃
Molecular Weight	300.48
Exact Mass	300.26600
PSA	57.53000
LogP	5.30330

HS Code	2918199090

Precursor 0
DownStream 1
4114-74-3

HS Code	2918199090
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%