185425-25-6

185425-25-6 structure

Name: Chimmitecan
Chemical Name: 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-,(4S)
CAS Number: 185425-25-6
Molecular Formula: C₂₃H₂₀N₂O₅
Molecular Weight: 404.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2018-06-27 11:33:11
Modify Date: 2024-01-12 18:02:10
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].

Name	1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-,(4S)
Synonyms	(S)-9-Allyl-10-hydroxycamptothecin UNII-889O97XDAD Chimmitecan

Description	Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13(4):1298-307.