33983-39-0
33983-39-0 structure
- Name: (6aS,11aS)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
- Chemical Name: (6aS,11aS)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
- CAS Number: 33983-39-0
- Molecular Formula: C16H14O4
- Molecular Weight: 270.28000
- Catalog: Research Areas Others
- Create Date: 2016-05-06 05:21:21
- Modify Date: 2024-01-02 12:13:40
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(±)-Medicarpin is a pterocarpan, a type of isoflavonoid. (±)-Medicarpin has been isolated from several medicinal plant species with various biological effects, including Sophora japonica as a phytoalexin, Zollernia paraensis and Platymiscium yucatamun with antifungal properties, Machaerium aristulatum, Platymiscium floribundum, and Brazilian red propolis with cytotoxic effects, and Dalbergia oliveri as a larvicidal compound. (±)-Medicarpin potently inhibits osteoclastogenesis and prevents estrogen-deficient bone loss but does not display uterine estrogenicity. It also promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1].
| Name | (6aS,11aS)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol |
|---|---|
| Synonyms | 3-Hydroxy-9-methoxypterocarpan |
| Description | (±)-Medicarpin is a pterocarpan, a type of isoflavonoid. (±)-Medicarpin has been isolated from several medicinal plant species with various biological effects, including Sophora japonica as a phytoalexin, Zollernia paraensis and Platymiscium yucatamun with antifungal properties, Machaerium aristulatum, Platymiscium floribundum, and Brazilian red propolis with cytotoxic effects, and Dalbergia oliveri as a larvicidal compound. (±)-Medicarpin potently inhibits osteoclastogenesis and prevents estrogen-deficient bone loss but does not display uterine estrogenicity. It also promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1]. |
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| Related Catalog | |
| Target |
ERβ |
| References |
[1]. Yang X, et al. Total Synthesis of (+)-Medicarpin. J Nat Prod. 2017 Dec 22;80(12):3284-3288. |
| Molecular Formula | C16H14O4 |
|---|---|
| Molecular Weight | 270.28000 |
| Exact Mass | 270.08900 |
| PSA | 47.92000 |
| LogP | 3.01050 |