1670-14-0

1670-14-0 structure

Name: Benzimidamide hydrochloride
Chemical Name: Benzamidine hydrochloride
CAS Number: 1670-14-0
Molecular Formula: C₇H₉ClN₂
Molecular Weight: 156.613
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2018-04-12 08:00:00
Modify Date: 2025-08-20 22:15:01
Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].

Name	Benzamidine hydrochloride
Synonyms	BENZAMIDE HCL H2O benzenecarboximidamide hydrochloride EINECS 216-795-4 benzamidinium chloride benzamidine-hydrochloride Benzamidine hydrochloride BENZAMIDINE HCL 2-phenylamidine hydrochloride Benzenecarboximidamide hydrochloride (1:1) benzamidine hydroxychloride Benzamidine hydrochl MFCD00013025 Additive Screening Benzamidine monohydrochloride AMIDINOBENZENE HYDROCHLORIDE amidinobenzenehydrochloride Benzamidin Hydrochloride Amidinobenzene hydrochloride (1:1) Benzenecarboximidamide, hydrochloride (1:1) Benzimidamide hydrochloride phenyl amidine hydrochloride

Description	Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1]
In Vitro	Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1].
References	[1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9. [2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

TOXIC EFFECTS :: Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CV6260000
HS Code	2925290090

613-92-3

~75%

1670-14-0

Literature: Mahajan, Umesh S.; Godinde, Rupesh R.; Mandhare Synthetic Communications, 2011 , vol. 41, # 15 p. 2195 - 2199

100-47-0

1670-14-0

Literature: Journal of Organometallic Chemistry, , vol. 331, # 2 p. 161 - 168

5873-90-5

1670-14-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 55, # 3 p. 372 - 375

7664-41-7

5333-86-8

1670-14-0

Literature: Die Imidoaether und ihre Derivate , S. 152

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%