119-15-3

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C12-H9-N3-O5

MOLECULAR WEIGHT :

275.24

WISWESSER LINE NOTATION :

WNR CNW DMR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15610 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5230 mg/kg

TOXIC EFFECTS :

Behavioral - food intake (animal) Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6550 mg/kg

TOXIC EFFECTS :

Behavioral - food intake (animal) Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

60 gm/kg/30D-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

33 ug/plate

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0745 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 741 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0745 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1125 (estimated) No. of Female Employees: 78 (estimated)