55974-42-0

55974-42-0 structure

Name: ARC 239 dihydrochloride
Chemical Name: 2-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-4,4-dimethyl-1,3(2 H,4H)-isoquinolinedione dihydrochloride
CAS Number: 55974-42-0
Molecular Formula: C₂₄H₃₁Cl₂N₃O₃
Molecular Weight: 480.42700
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-02-23 04:49:55
Modify Date: 2024-01-16 21:02:13
ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pKis of 5.6, 8.4, and 7.08, respectively[1].

Name	2-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-4,4-dimethyl-1,3(2 H,4H)-isoquinolinedione dihydrochloride
Synonyms	Pertussis Toxin

Description	ARC 239 dihydrochloride is a selective α2B/2C adrenoceptor antagonist (pKd values are 5.95, 7.41 and 7.56 at α2A, α2B, and α2C receptors respectively). ARC 239 dihydrochloride binds to CHO cell membranes expressing human recombinant a2A-, a2B- or a2C-adrenoceptor subtypes with pKis of 5.6, 8.4, and 7.08, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
Target	Alpha-2B adrenergic receptor 5-HT1A Receptor
References	[1]. M R Corboz, et al. Pharmacological characterization of alpha 2-adrenoceptor-mediated responses in pig nasal mucosa. Auton Autacoid Pharmacol. 2003 Aug;23(4):208-19.