171596-27-3

171596-27-3 structure

Name: 12-epi-TadalafilTadalafil
Chemical Name: (6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
CAS Number: 171596-27-3
Molecular Formula: C₂₂H₁₉N₃O₄
Molecular Weight: 389.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-08-31 19:16:30
Modify Date: 2025-08-20 18:30:43
cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].

Name	(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
Synonyms	UNII-E319TQ0B6R cis-ent-Tadalafil PYR403 12-epi-TadalafilTadalafil Tadalafil Impurity 13

Description	cis-Tadalafil is a PDE5 inhibitor (IC50: 0.09 μM). cis-Tadalafil can be used for research of cardiovascular diseases[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	PDE5:0.09 μM (IC50)
In Vitro	cis-Tadalafil (Compound 12b) 抑制 PDE5，IC50 为 0.09 μM[1]。
References	[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.

171596-29-5

~95%

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Literature: Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442

74-89-5

629652-44-4

~81%

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Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

74-89-5

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~1%

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Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

120-57-0

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Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

4299-70-1

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Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

171596-44-4

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Literature: Journal of Medicinal Chemistry, , vol. 46, # 21 p. 4533 - 4542

14907-27-8

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Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515

171596-41-1

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Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515