9041-22-9

9041-22-9 structure

Name: beta-D-Glucan
Chemical Name: β-D-Glucan
CAS Number: 9041-22-9
Molecular Formula: C₁₈H₃₂O₁₆
Molecular Weight: 504.437
Catalog: analytical chemistry Analytical reagent Common analytical reagents
Create Date: 2018-04-22 08:00:00
Modify Date: 2024-01-02 11:53:06
β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery[1]. β-d-glucan is an enteric delivery vehicle for probiotics[2].

Name	β-D-Glucan
Synonyms	β-D-Glucopyranosyl-(1->4)-(4ξ)-β-D-xylo-hexopyranosyl-(1->4)-(4ξ)-α-D-xylo-hexopyranose Carbamic acid,(1,1-dimethyl-2-propynyl)-,2-fluoroethyl ester α-D-xylo-Hexopyranose, O-β-D-glucopyranosyl-(1->4)-O(4ξ)-β-D-xylo-hexopyranosyl-(1->4)-, (4ξ)- beta-D-Glucan

Description	β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery[1]. β-d-glucan is an enteric delivery vehicle for probiotics[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
In Vitro	β-D-glucan dissolved in DMSO but not water inhibits MCF-7 cell proliferation in a concentration-dependent manner as measured by BrdU incorporation with an IC50 of ∼164 μg/mL. β-D-glucan dissolved in DMSO inhibits tamoxifen/endocrine-resistant LCC9 and LY2 cell proliferation with IC50 values of 4.6 and 24.2 μg/mL, respectively[3].
References	[1]. Su Y, et al. pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery. Carbohydr Polym. 2020;246:116621. [2]. Gani A, et al. β-d-glucan as an enteric delivery vehicle for probiotics. Int J Biol Macromol. 2018;106:864-869. [3]. Jafaar ZM, et al. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014;44(4):1365-1375.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ3985000